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Emerging Therapies for Glioblastoma

Cancers, ISSN: 2072-6694, Vol: 16, Issue: 8
2024
  • 5
    Citations
  • 51
    Usage
  • 53
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

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Most Recent News

University of Texas Rio Grande Valley Researcher Focuses on Cancer Gene Therapy (Emerging Therapies for Glioblastoma)

2024 APR 25 (NewsRx) -- By a News Reporter-Staff News Editor at Cancer Gene Therapy Daily -- Fresh data on cancer gene therapy are presented

Review Description

Glioblastoma is most commonly a primary brain tumor and the utmost malignant one, with a survival rate of approximately 12–18 months. Glioblastoma is highly heterogeneous, demonstrating that different types of cells from the same tumor can manifest distinct gene expression patterns and biological behaviors. Conventional therapies such as temozolomide, radiation, and surgery have limitations. As of now, there is no cure for glioblastoma. Alternative treatment methods to eradicate glioblastoma are discussed in this review, including targeted therapies to PI3K, NFKβ, JAK-STAT, CK2, WNT, NOTCH, Hedgehog, and TGFβ pathways. The highly novel application of oncolytic viruses and nanomaterials in combating glioblastoma are also discussed. Despite scores of clinical trials for glioblastoma, the prognosis remains poor. Progress in breaching the blood–brain barrier with nanomaterials and novel avenues for targeted and combination treatments hold promise for the future development of efficacious glioblastoma therapies.

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