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Testing the Hypothesis of Accelerated Cerebral White Matter Aging in Schizophrenia and Major Depression

Biological Psychiatry, ISSN: 0006-3223, Vol: 73, Issue: 5, Page: 482-491
2013
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Metric Options:   Counts1 Year3 Year

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Article Description

Elevated rate of aging-related biological and functional decline, termed “accelerated aging,” is reported in patients with schizophrenia (SCZ) and major depressive disorder (MDD). We used diffusion tensor imaging derived fractional anisotropy (FA) as a biomarker of aging-related decline in white matter (WM) integrity to test the hypotheses of accelerated aging in SCZ and MDD.

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