Synergistic effects of traumatic head injury and apolipoprotein-ε4 in patients with Alzheimer's disease
Neurology, ISSN: 0028-3878, Vol: 45, Issue: 3 I, Page: 555-557
1995
- 544Citations
- 159Usage
- 152Captures
- 3Mentions
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Metrics Details
- Citations544
- Citation Indexes541
- 541
- CrossRef415
- Policy Citations2
- Policy Citation2
- Clinical Citations1
- PubMed Guidelines1
- Usage159
- Downloads148
- Abstract Views11
- Captures152
- Readers152
- 152
- Mentions3
- Blog Mentions2
- Blog2
- References1
- Wikipedia1
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Article Description
The apolipoprotein-ε4 allele increases the risk of Alzheimer's disease (AD), but cerebral deposition of β-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolipoprotein-ε4 in 236 community-dwelling elderly persons. A 10-fold increase in the risk of AD was associated with both apolipoprotein-ε4 and a history of traumatic head injury, compared with a two-fold increase in risk with apolipoprotein- ε4 alone. Head injury in the absence of an apolipoprotein-ε4 allele did not increase risk. These data imply that the biological effects of head injury may increase the risk of AD, but only through a synergistic relationship with apolipoprotein-ε4.
Bibliographic Details
http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029018224&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7898715; http://dx.doi.org/10.1212/wnl.45.3.555; https://www.neurology.org/doi/10.1212/WNL.45.3.555; https://scholarworks.utrgv.edu/som_pub/41; https://scholarworks.utrgv.edu/cgi/viewcontent.cgi?article=1040&context=som_pub; https://dx.doi.org/10.1212/wnl.45.3.555; https://n.neurology.org/content/45/3/555; https://n.neurology.org/content/45/3/555.abstract; https://n.neurology.org/content/neurology/45/3/555.full.pdf; http://www.neurology.org/cgi/doi/10.1212/WNL.45.3.555; http://n.neurology.org/content/45/3/555; http://n.neurology.org/content/45/3/555.abstract; http://n.neurology.org/content/45/3/555.full.pdf; http://www.neurology.org/lookup/doi/10.1212/WNL.45.3.555
Ovid Technologies (Wolters Kluwer Health)
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