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Optimization of solid-supported Glaser-Hay reactions in the microwave

Molecules, ISSN: 1420-3049, Vol: 20, Issue: 4, Page: 5276-5285
2015
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Article Description

The translation of organometallic reactions into a microwave reactor has numerous advantages. Herein, we describe the application of a previously developed solid-supported Glaser-Hay reaction to microwave conditions. Overall, an array of diynes has been prepared demonstrating the ability to conduct chemoselective reactions in the microwave within 20 min compared to the 16 h thermal conditions. Moreover, non-microwave transparent alkynes have been found to react more quickly, preventing catalyst quenching, and resulting in higher yields.

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