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Kinomic exploration of temozolomide and radiation resistance in Glioblastoma multiforme xenolines

Radiotherapy and Oncology, ISSN: 0167-8140, Vol: 111, Issue: 3, Page: 468-474
2014
  • 35
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  • 192
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  • 42
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  • 0
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  • 0
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Metric Options:   Counts1 Year3 Year

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Article Description

Glioblastoma multiforme (GBM) represents the most common and deadly primary brain malignancy, particularly due to temozolomide (TMZ) and radiation (RT) resistance. To better understand resistance mechanisms, we examined global kinase activity (kinomic profiling) in both treatment sensitive and resistant human GBM patient-derived xenografts (PDX or “xenolines”).

Bibliographic Details

http://www.sciencedirect.com/science/article/pii/S016781401400173X; http://dx.doi.org/10.1016/j.radonc.2014.04.010; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84905225833&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24813092; https://linkinghub.elsevier.com/retrieve/pii/S016781401400173X; https://scholarworks.wm.edu/rbc_facwork/12; https://scholarworks.wm.edu/cgi/viewcontent.cgi?article=1010&context=rbc_facwork; http://www.thegreenjournal.com/article/S0167-8140(14)00173-X/abstract; http://linkinghub.elsevier.com/retrieve/pii/S016781401400173X; https://secure.jbs.elsevierhealth.com/action/getSharedSiteSession?redirect=http%3A%2F%2Fwww.thegreenjournal.com%2Farticle%2FS0167-8140%2814%2900173-X%2Fabstract&rc=0&code=radion-site; http://acw.elsevier.com/SSOCore?return=https%3A%2F%2Fsecure.jbs.elsevierhealth.com%2Faction%2FconsumeSsoCookie%3FredirectUri%3Dhttp%253A%252F%252Fwww.thegreenjournal.com%252Faction%252FconsumeSharedSessionAction%253FJSESSIONID%253Daaa_7fsyCzQ04-ZPgjnxv%2526MAID%253DArEdGYcIXsdYInKv9%25252B9EHA%25253D%25253D%2526SERVER%253DWZ6myaEXBLF%25252FdY29RpN4fA%25253D%25253D%2526ORIGIN%253D16060517%2526RD%253DRD; http://acw.elsevier.com/SSOCore/?return=https%3A%2F%2Fsecure.jbs.elsevierhealth.com%2Faction%2FconsumeSsoCookie%3FredirectUri%3Dhttp%253A%252F%252Fwww.thegreenjournal.com%252Faction%252FconsumeSharedSessionAction%253FJSESSIONID%253Daaa_7fsyCzQ04-ZPgjnxv%2526MAID%253DArEdGYcIXsdYInKv9%25252B9EHA%25253D%25253D%2526SERVER%253DWZ6myaEXBLF%25252FdY29RpN4fA%25253D%25253D%2526ORIGIN%253D16060517%2526RD%253DRD; https://secure.jbs.elsevierhealth.com/action/consumeSsoCookie?redirectUri=http%3A%2F%2Fwww.thegreenjournal.com%2Faction%2FconsumeSharedSessionAction%3FJSESSIONID%3Daaa_7fsyCzQ04-ZPgjnxv%26MAID%3DArEdGYcIXsdYInKv9%252B9EHA%253D%253D%26SERVER%3DWZ6myaEXBLF%252FdY29RpN4fA%253D%253D%26ORIGIN%3D16060517%26RD%3DRD&acw=&utt=

Anderson, Joshua C; Duarte, Christine W; Welaya, Karim; Rohrbach, Timothy D; Bredel, Markus; Yang, Eddy S; Choradia, Nirmal V; Thottassery, Jaideep V; Yancey Gillespie, George; Bonner, James A; Willey, Christopher D

Elsevier BV

Medicine

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