Effects on cell viability and cell cycle of apigenin on BCPAP cell line of thyroid cancer
Vol: 31, Issue: 3, Page: 3-7
2015
- 21Usage
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Usage21
- Downloads17
- Abstract Views4
Artifact Description
To investigate the effects on cell viability and cell cycle of apigenin on BCPAP cell line, the MTT assay was used to detect the growth inhibition rates of BCPAP cells at 24 h which cultured with apigenin in different concentrations, and of BCPAP cells at 24, 48, 72 h which cultured with 12.5, 25, 50 μmol/L apigenin as well. The bright field images of cell morphology were analyzed. The effects were evaluated of different concentration of apigenin on the morphology of BCPAP cells, and the inhibition of cell growth. The cell cycle distribution was measured by flow cytometry. The different concentrations (12.5~100 μmol/L) of apigenin had cytotoxicity on BCPAP cells, which were clearly dose-and time-dependent. The IC50 of 24 h is 40.65 μmol/L. There are significant effects of apigenin on the morphological changes of BCPAP cells, and the high concentration of apigenin strongly inhibited BCPAP cell growth in numbers. Cells were treated with apigenin which had significant effects on cell cycle of BCPAP cell, and induced apoptosis. Apigenin had significant cytotoxicity and inhibition of cell viability on thyroid cancer BCPAP cells. One of the mechanisms may be that it might make significant G2/M phase arrest and induced apoptosis, and a decrease of cell viability, then the cell number was declined.
Bibliographic Details
https://www.ifoodmm.cn/journal/vol31/iss3/1; https://www.ifoodmm.cn/cgi/viewcontent.cgi?article=4618&context=journal; http://dx.doi.org/10.13652/j.issn.1003-5788.2015.03.001; https://dx.doi.org/10.13652/j.issn.1003-5788.2015.03.001; https://www.chndoi.org/Resolution/Handler?doi=10.13652/j.issn.1003-5788.2015.03.001
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know