High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors.

Citation data:

Haematologica, ISSN: 1592-8721, Vol: 95, Issue: 9, Page: 1519-25

Publication Year:
2010
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Repository URL:
http://arrow.dit.ie/scschbioart/10; http://arrow.dit.ie/scschbioart/71
PMID:
20421269
DOI:
10.3324/haematol.2009.021014
PMCID:
PMC2930953
Author(s):
Marincevic, Millaray; Cahill, Nicola; Gunnarsson, Rebeqa; Isaksson, Anders; Mansouri, Mahmoud; Göransson, Hanna; Rasmussen, Markus; Jansson, Mattias; Ryan, Fergus; Karlsson, Karin; Adami, Hans-Olov; Davi, Fred; Jurlander, Jesper; Juliusson, Gunnar; Stamatopoulos, Kostas; Rosenquist, Richard Show More Hide
Publisher(s):
Ferrata Storti Foundation (Haematologica); Dublin Institute of Technology
Tags:
Medicine; chronic lymphocytic leukemia; stereotyped B-cell receptors; antigens; leukemogenesis; sterotyped B-cell receptors; 3. MEDICAL AND HEALTH SCIENCES; Bioinformatics; Genetics; Laboratory and Basic Science Research; Medical Molecular Biology; Molecular Genetics; 1.6 BIOLOGICAL SCIENCES; Life Sciences
article description
The existence of multiple subsets of chronic lymphocytic leukemia expressing 'stereotyped' B-cell receptors implies the involvement of antigen(s) in leukemogenesis. Studies also indicate that 'stereotypy' may influence the clinical course of patients with chronic lymphocytic leukemia, for example, in subsets with stereotyped IGHV3-21 and IGHV4-34 B-cell receptors; however, little is known regarding the genomic profile of patients in these subsets.