Synthesis, Characterization, and Applications of Dendrimers

Publication Year:
2015
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Repository URL:
https://bearworks.missouristate.edu/theses/1999
Author(s):
Dou, Xiaozheng none
Tags:
copolymer; dendrimer; PEG; micelle; drug delivery; phase transfer catalyst; gene delivery; Chemistry
artifact description
In this work, I have synthesized a series of poly(ethylene glycol)-block-polyamide dendrimers and have characterized them by NMR spectroscopy. I have also studied the potential applications of methoxy poly(ethylene glycol)-block-poly(ether sulfide) [or mPEG-block-poly(ether sulfide)] dendrimers in drug delivery by examining the solubility of pyrene in water in the presence of the various concentrations of the dendrimers. It was found that generation 3 of mPEG-block-poly(ether sulfide) dendrimer modestly increased the solubility of pyrene in water. Applications of these dendrimers as phase transfer catalysts have also been investigated. It was found that generation 3 of mPEG-block-poly(ether sulfide) dendrimer acted as an excellent phase transfer catalyst in the dehydrohalogenation of 2-bromoethyl benzene. The effect of mPEG-block-poly(ether sulfide) dendrimer on calf-thymus DNA has also been investigated by circular dichroism (CD). Finally, the effects of mPEG and mPEG-block-poly(amido amine) dendrimers on Dickerson-Drew Dodecamer DNA have been studied by NMR spectroscopy and CD and the results are presented and discussed.