Evidence for a role of endocannabinoids, astrocytes and p38 phosphorylation in the resolution of postoperative pain.

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PloS one, ISSN: 1932-6203, Vol: 5, Issue: 5, Page: e10891

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10.1371/journal.pone.0010891; 10.1371/journal.pone.0010891.g007; 10.1371/journal.pone.0010891.g006; 10.1371/journal.pone.0010891.g009; 10.1371/journal.pone.0010891.g003; 10.1371/journal.pone.0010891.g002; 10.1371/journal.pone.0010891.g004; 10.1371/journal.pone.0010891.g001; 10.1371/journal.pone.0010891.g008; 10.1371/journal.pone.0010891.g005
PMC2878341; 2878341
Matthew S. Alkaitis; Carlos Solorzano; Russell P. Landry; Daniele Piomelli; Joyce A. DeLeo; E. Alfonso Romero-Sandoval; Michelle L. Block
Public Library of Science (PLoS); Figshare
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; animals; astrocytes; behavior; animal; biomarkers; calcium-binding proteins; cannabinoid receptor modulators; endocannabinoids; glial fibrillary acidic protein; male; microfilament proteins; neuroglia; pain; postoperative; phosphorylation; rats; sprague-dawley; receptor; cb1; cannabinoid; cb2; spinal cord; xanthines; p38 mitogen-activated protein kinases; aif1 protein; rat; Cell Biology; Neuroscience; receptors; microglial; reverses; over-expression; gfap; phospho-p38; treated; dual; blockade; persistent; p38; Medicine and Health Sciences; prevents; paw; incision-induced; allodynia; glial; spontaneously; hypersensitivity; perivascular; endocannabinoid; levels; dynamically; regulated
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An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying the transition from acute to chronic pain states are not fully understood. In general, endocannabinoids (ECBs) inhibit nociceptive processing by stimulating cannabinoid receptors type 1 (CB(1)) and type 2 (CB(2)). We have previously shown that intrathecal administration of a CB(2) receptor agonist reverses both surgical incision-induced behavioral hypersensitivity and associated over-expression of spinal glial markers. We therefore hypothesized that endocannabinoid signaling promotes the resolution of acute postoperative pain by modulating pro-inflammatory signaling in spinal cord glial cells.