CCR5 mediates specific migration of Toxoplasma gondii —primed CD8 + lymphocytes to inflammatory intestinal epithelial cells

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Gastroenterology, ISSN: 0016-5085, Vol: 125, Issue: 2, Page: 491-500

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Souphalone Luangsay; Lloyd H. Kasper; Nicolas Rachinel; Laurie A. Minns; Franck J.D. Mennechet; Alain Vandewalle; Dominique Buzoni-Gatel
Elsevier BV
Medicine; cfse; 5(6) carboxyfluorescein diacetate; succinimidyl ester; iec; intestinal epithelial cell; iel; intraepithelial lymphocyte; il; interleukin; ip-10; interferon γ—inducible 10-kilodalton protein; mip; macrophage inflammatory protein; mcp; monocyte chemoattractant protein; rantes; regulated upon activation; normal t cell expressed and secreted protein; tgf; transforming growth factor; wt; wild-type; Digestive System Diseases; Gastroenterology; Medicine and Health Sciences
article description
Toxoplasma gondii, an obligate intracellular parasite, can invade intestinal epithelial cells and elicit a robust Th1 immune response. In this model of intestinal inflammation, CD8 + intraepithelial lymphocytes (IELs) secrete transforming growth factor (TGF)-β, which appears necessary for the maintenance of homeostasis in the intestine. However, the mechanism responsible for the IEL migration to the inflamed intestine is still unclear.