Gene response profiles for Daphnia pulex exposed to the environmental stressor cadmium reveals novel crustacean metallothioneins.

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BMC genomics, ISSN: 1471-2164, Vol: 8, Issue: 1, Page: 477

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10.1186/1471-2164-8-477; 10.3410/f.1097571.553657
Shaw, Joseph R; Colbourne, John K; Davey, Jennifer C; Glaholt, Stephen P; Hampton, Thomas H; Chen, Celia Y; Folt, Carol L; Hamilton, Joshua W
Springer Nature; Faculty of 1000, Ltd.
Biochemistry, Genetics and Molecular Biology; animals; biomarkers; cadmium; toxicity; dna; complementary; daphnia; genetics; metabolism; databases; genetic; dose-response relationship; drug; environmental monitoring; gene expression profiling; gene expression regulation; drug effects; genome; metallothionein; molecular sequence data; oligonucleotide array sequence analysis; phylogeny; reverse transcriptase polymerase chain reaction; water pollutants; chemical; Genetics and Genomics; Genomics; Life Sciences
article description
Genomic research tools such as microarrays are proving to be important resources to study the complex regulation of genes that respond to environmental perturbations. A first generation cDNA microarray was developed for the environmental indicator species Daphnia pulex, to identify genes whose regulation is modulated following exposure to the metal stressor cadmium. Our experiments revealed interesting changes in gene transcription that suggest their biological roles and their potentially toxicological features in responding to this important environmental contaminant.