Therapeutic Targeting of ATP7B in Ovarian Carcinoma.

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Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN: 1078-0432, Vol: 15, Issue: 11, Page: 3770-80

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Mangala, Lingegowda S; Zuzel, Vesna; Schmandt, Rosemarie; Leshane, Erik S; Halder, Jyotsna B; Armaiz-Pena, Guillermo N; Spannuth, Whitney A; Tanaka, Takemi; Shahzad, Mian M K; Lin, Yvonne G; Nick, Alpa M; Danes, Christopher G; Lee, Jeong-Won; Jennings, Nicholas B; Vivas-Mejia, Pablo E; Wolf, Judith K; Coleman, Robert L; Siddik, Zahid H; Lopez-Berestein, Gabriel; Lutsenko, Svetlana; Sood, Anil K Show More Hide
American Association for Cancer Research (AACR); The Association
Medicine; Biochemistry, Genetics and Molecular Biology; Adenosine Triphosphatases; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Blotting; Western; Cation Transport Proteins; Cell Line; Tumor; Cell Proliferation; Cell Survival; Cisplatin; DNA Adducts; Drug Resistance; Neoplasm; Female; Humans; Immunohistochemistry; Mice; Nude; Ovarian Neoplasms; Protein Binding; RNA Interference; Reverse Transcriptase Polymerase Chain Reaction; Tumor Burden; Xenograft Model Antitumor Assays; Medicine and Health Sciences
article description
Resistance to platinum chemotherapy remains a significant problem in ovarian carcinoma. Here, we examined the biological mechanisms and therapeutic potential of targeting a critical platinum resistance gene, ATP7B, using both in vitro and in vivo models.