The Skeptical Raptor, stalking pseudoscience in the internet jungle. There are so many annoying issues about the antivaccination cult, th...
Immunologic Memory to Polysaccharide Antigens
- Publication Year:
- Usage 451
- Abstract Views 273
- Bepress 273
- Downloads 178
- Bepress 178
- Mentions 2
- Blog Mentions 2
- Blogs 2
- polysaccharide antigens; immunologic memory; type II antigens; memory B cells; Life Sciences
- Most Recent Tweet View All Tweets
- Most Recent Blog Mention
thesis / dissertation description
Immunologic memory is the ability of the immune system to generate an enhanced antibody response against previously encountered antigens. The clonal selection theory of acquired immunity attributes immunologic memory to the formation of an expanded compartment of quiescent antigen-specific memory B cells that are capable of rapid activation upon secondary antigen encounter. Whereas protein antigens are known to elicit memory B cells, it is not known whether polysaccharide antigens do. Here we report that polysaccharide antigens elicit memory B cells that are phenotypically distinct from those elicited by protein antigens. We show that antigen affinity of the B cell receptor regulates the development of memory B cells and that antigen-specific IgG antibodies suppress recall responses against polysaccharides via a mechanism that does not depend on epitope masking or involve known Fey receptors.