CD8 memory T cells: cross-reactivity and heterologous immunity.

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Seminars in immunology, ISSN: 1044-5323, Vol: 16, Issue: 5, Page: 335-47

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Selin, Liisa K.; Cornberg, Markus; Brehm, Michael A.; Kim, Sung-Kwon; Calcagno, Claudia; Ghersi, Dario; Puzone, Roberto; Celada, Franco; Welsh, Raymond M.
Elsevier BV
Medicine; Immunology and Microbiology; Memory T cell; Heterologous immunity; Cross-reactive; Allo-reactive; Memory attrition; Bioinformatics
review description
Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.