CD8 memory T cells: cross-reactivity and heterologous immunity.
- Citation data:
Seminars in immunology, ISSN: 1044-5323, Vol: 16, Issue: 5, Page: 335-47
- Publication Year:
- Repository URL:
- https://works.bepress.com/dario-ghersi/15; https://digitalcommons.unomaha.edu/interdiscipinformaticsfacpub/18
- Medicine; Immunology and Microbiology; Memory T cell; Heterologous immunity; Cross-reactive; Allo-reactive; Memory attrition; Bioinformatics
Virus-specific memory T cell populations demonstrate plasticity in antigen recognition and in their ability to accommodate new memory T cell populations. The degeneracy of T cell antigen recognition and the flexibility of diverse antigen-specific repertoires allow the host to respond to a multitude of pathogens while accommodating these numerous large memory pools in a finite immune system. These cross-reactive memory T cells can be employed in immune responses and mediate protective immunity, but they can also induce life-threatening immunopathology or impede transplantation tolerance and graft survival. Here we discuss examples of altered viral pathogenesis occurring as a consequence of heterologous T cell immunity and propose models for the maintenance of a dynamic pool of memory cells.