Synthesis and Characterization of Nanocomposite Microparticles (nCmP) for the Treatment of Cystic Fibrosis-Related Infections.

Citation data:

Pharmaceutical research, ISSN: 1573-904X, Vol: 33, Issue: 8, Page: 1862-72

Publication Year:
2016
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Repository URL:
http://digitalcommons.uri.edu/che_facpubs/30; https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1032&context=che_facpubs
PMID:
27091030
DOI:
10.1007/s11095-016-1921-5
PMCID:
PMC4945441
Author(s):
Wang, Zimeng; Meenach, Samantha A.
Publisher(s):
Springer Nature; DigitalCommons@URI
Tags:
Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry; Medicine
article description
Pulmonary antibiotic delivery is recommended as maintenance therapy for cystic fibrosis (CF) patients who experience chronic infections. However, abnormally thick and sticky mucus present in the respiratory tract of CF patients impairs mucus penetration and limits the efficacy of inhaled antibiotics. To overcome the obstacles of pulmonary antibiotic delivery, we have developed nanocomposite microparticles (nCmP) for the inhalation application of antibiotics in the form of dry powder aerosols.