Folic acid supplementation increases survival and modulates high risk HPV-induced phenotypes in oral squamous cell carcinoma cells and correlates with p53 mRNA transcriptional down-regulation.

Citation data:

Cancer cell international, ISSN: 1475-2867, Vol: 12, Issue: 1, Page: 10

Publication Year:
2012
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Repository URL:
https://digitalscholarship.unlv.edu/dental_fac_articles/20; http://ezproxy.library.unlv.edu/login?url=http://dx.doi.org/10.1186/1475-2867-12-10
PMID:
22443202
DOI:
10.1186/1475-2867-12-10
PMCID:
PMC3340312
Author(s):
Moody, Michael; Le, Oanh; Rickert, Megan; Manuele, Jeremy; Chang, Sarah; Robinson, Gary; Hajibandeh, Jeffrey; Silvaroli, John; Keiserman, Mark A.; Bergman, Christine J.; Kingsley, Karl Show More Hide
Publisher(s):
Springer Nature
Tags:
Medicine; Biochemistry, Genetics and Molecular Biology; Folate; Human papillomavirus; Oral cancer
article description
Although the primary risk factors for developing oral cancers are well understood, less is known about the relationship among the secondary factors that may modulate the progression of oral cancers, such as high-risk human papillomavirus (HPV) infection and folic acid (FA) supplementation. This study examined high-risk HPV and FA supplementation effects, both singly and in combination, to modulate the proliferative phenotypes of the oral cancer cell lines CAL27, SCC25 and SCC15.