Population-specific evolution of HIV Gag epitopes in genetically diverged patients.

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Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, ISSN: 1567-7257, Vol: 16, Page: 78-86

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Repository URL:
https://ecommons.aku.edu/pakistan_fhs_mc_surg_urol/17; https://ecommons.aku.edu/eastafrica_fhs_mc_pathol/36; https://works.bepress.com/farhat_abbas/36
Abidi, Syed H.; Shahid, Aniqa; Lakhani, Laila S.; Khanani, Muhammad R.; Ojwang, Peter; Okinda, Nancy; Shah, Reena; Abbas, Farhat; Rowland-Jones, Sarah; Ali, Syed
Elsevier BV
Immunology and Microbiology; Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; HIV; Epitope; Kenya; Pakistan; Pathology; Surgery; Urology
article description
Under the host selection pressure HIV evolves rapidly to override crucial steps in the antigen presentation pathway. This allows the virus to escape binding and recognition by cytotoxic T lymphocytes. Selection pressures on HIV can be unique depending on the immunogenetics of host populations. It is therefore logical to hypothesize that the virus evolving in a given population will carry signature mutations that will allow it to survive in that particular host milieu.