Pharmacokinetics of aditoprim and trimethoprim in buffalo calves

Citation data:

Biopharmaceutics & Drug Disposition, ISSN: 1099-081X, Vol: 15, Issue: 2, Page: 173-177

Publication Year:
1994
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Repository URL:
https://ecommons.aku.edu/pakistan_fhs_mc_bbs/578
DOI:
10.1002/bdd.2510150209
Author(s):
M. Perwaiz Iqbal; M. Khalid Ashfaq; M. Mahboobali; Sarfaraz K. Niazi; Khalid N. Khawaja
Publisher(s):
Wiley
Tags:
Pharmacology, Toxicology and Pharmaceutics; Medicine; Biochemistry
article description
Pharmacokinetic parameters of two antifolates, trimethoprim and aditoprim, were studied in buffalo calves. The elimination half‐life of aditoprim (6.14 h) was nearly twice as long as that of trimethoprim (3.08 h) and compares well with values observed in heifers. This longer half‐life of aditoprim is a result of its much larger distribution volume (four to five times larger) because the clearance of aditoprim was about twice as high as that of trimethoprim. The longer half‐life of aditoprim is expected to give a longer duration of in vivo bacteriostatic activity than that of trimethoprim. Copyright © 1994 John Wiley & Sons, Ltd.