The pharmacology of estradiol, an estrogen medication and naturally occurring steroid hormone, concerns its pharmacodynamics, pharmacokinetics, and various routes of administration cite book Estradiol is a naturally occurring and bioidentical estrogen, or an agonist of the est...
TRANSDERMAL ESTRADIOL THERAPY FOR PROSTATE CANCER REDUCES THROMBOPHILIC ACTIVATION AND PROTECTS AGAINST THROMBOEMBOLISM
- Citation data:
The Journal of Urology, ISSN: 0022-5347, Vol: 174, Issue: 2, Page: 527-533
- Publication Year:
- Repository URL:
- https://ecommons.aku.edu/pakistan_fhs_mc_pathol_microbiol/333; https://works.bepress.com/elnasir_lalani/90
- Medicine; Prostatic neoplasms; Estradiol; Cutaneous administration; Thrombosis; Male Urogenital Diseases; Oncology; Pathology
Oral estrogens were an effective treatment for prostate cancer but were abandoned because of an increased risk of cardiovascular toxicity and particularly thromboembolism. We have recently shown that transdermal estradiol produces an effective tumor response and negligible cardiovascular toxicity. Here we report the influence of transdermal estradiol therapy on the coagulation profile of men with advanced prostate cancer.