Two distinct patterns of treatment resistance: clinical predictors of treatment resistance in first-episode schizophrenia spectrum psychoses.

Citation data:

Psychological medicine, ISSN: 1469-8978, Vol: 46, Issue: 15, Page: 3231-3240

Publication Year:
2016
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Citations 32
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Repository URL:
https://epubs.rcsi.ie/psychart/39
PMID:
27605254
DOI:
10.1017/s0033291716002014
Author(s):
Lally, John; Ajnakina, Olesya; Di Forti, Marta; Trotta, Antonella; Demjaha, Arsime; Kolliakou, Anna; Mondelli, Valeria; Reis Marques, Tiago; Pariante, Carmine; Dazzan, Paola; Shergil, Sukhwinder S; Howes, Oliver D; David, Athony S; MacCabe, James H; Gaughran, Fiona; Murray, Robin M Show More Hide
Publisher(s):
Cambridge University Press (CUP); Cambridge University Press
Tags:
Psychology; Medicine; Clozapine; first-episode psychosis; longitudinal; schizophrenia; treatment-resistant.; Medicine and Health Sciences; Psychiatry and Psychology
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article description
Clozapine remains the only evidence-based antipsychotic for treatment-resistant schizophrenia (TRS). The ability to predict which patients with their first onset of schizophrenia would subsequently meet criteria for treatment resistance (TR) could help to diminish the severe functional disability which may ensue if TR is not recognized and correctly treated.