Two distinct patterns of treatment resistance: clinical predictors of treatment resistance in first-episode schizophrenia spectrum psychoses.

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Psychological medicine, ISSN: 1469-8978, Vol: 46, Issue: 15, Page: 3231-3240

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Lally, John; Ajnakina, Olesya; Di Forti, Marta; Trotta, Antonella; Demjaha, Arsime; Kolliakou, Anna; Mondelli, Valeria; Reis Marques, Tiago; Pariante, Carmine; Dazzan, Paola; Shergil, Sukhwinder S; Howes, Oliver D; David, Athony S; MacCabe, James H; Gaughran, Fiona; Murray, Robin M Show More Hide
Cambridge University Press (CUP); Cambridge University Press
Psychology; Medicine; Clozapine; first-episode psychosis; longitudinal; schizophrenia; treatment-resistant.; Medicine and Health Sciences; Psychiatry and Psychology
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article description
Clozapine remains the only evidence-based antipsychotic for treatment-resistant schizophrenia (TRS). The ability to predict which patients with their first onset of schizophrenia would subsequently meet criteria for treatment resistance (TR) could help to diminish the severe functional disability which may ensue if TR is not recognized and correctly treated.