Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis.

Citation data:

Blood, ISSN: 1528-0020, Vol: 118, Issue: 12, Page: 3290-300

Publication Year:
2011
Usage 17
Abstract Views 17
Captures 56
Readers 56
Citations 80
Citation Indexes 80
Repository URL:
https://escholarship.umassmed.edu/davis/45
PMID:
21791428
DOI:
10.1182/blood-2011-02-336552
PMCID:
PMC3179398
Author(s):
Noubade, Rajkumar; Krementsov, Dimitry N.; Del Rio, Roxana; Thornton, Tina; Nagaleekar, Viswas; Saligrama, Naresha; Spitzack, Anthony; Spach, Karen; Sabio, Guadalupe; Davis, Roger J.; Rincon, Mercedes; Teuscher, Cory Show More Hide
Publisher(s):
American Society of Hematology
Tags:
Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine; Animals; Antibodies, Monoclonal; *Autoimmunity; Cell Proliferation; Cell Separation; Cells, Cultured; Chronic Disease; Encephalomyelitis, Autoimmune,; Experimental; Eukaryotic Initiation Factor-4E; Female; Flow Cytometry; Humans; Interleukin-17; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Phosphorylation; Polymerase Chain Reaction; Signal Transduction; Th17 Cells; p38 Mitogen-Activated Protein Kinases; Biochemistry; Cell Biology; Cellular and Molecular Physiology; Molecular Biology
article description
Although several transcription factors have been shown to be critical for the induction and maintenance of IL-17 expression by CD4 Th cells, less is known about the role of nontranscriptional mechanisms. Here we show that the p38 MAPK signaling pathway is essential for in vitro and in vivo IL-17 production by regulating IL-17 synthesis in CD4 T cells through the activation of the eukaryotic translation initiation factor 4E/MAPK-interacting kinase (eIF-4E/MNK) pathway. We also show that p38 MAPK activation is required for the development and progression of both chronic and relapsing-remitting forms of experimental allergic encephalomyelitis (EAE), the principal autoimmune model of multiple sclerosis. Furthermore, we show that regulation of p38 MAPK activity specifically in T cells is sufficient to modulate EAE severity. Thus, mechanisms other than the regulation of gene expression also contribute to Th17 cell effector functions and, potentially, to the pathogenesis of other Th17 cell-mediated diseases.