Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice.

Citation data:

Liver international : official journal of the International Association for the Study of the Liver, ISSN: 1478-3231, Vol: 37, Issue: 7, Page: 968-973

Publication Year:
2017
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Repository URL:
https://escholarship.umassmed.edu/faculty_pubs/1194; https://works.bepress.com/arvin_iracheta-vellve/11; https://works.bepress.com/gyongyi_szabo/209
PMID:
28345165
DOI:
10.1111/liv.13430
Author(s):
Iracheta-Vellve, Arvin; Petrasek, Jan; Gyongyosi, Benedek; Bala, Shashi; Csak, Timea; Kodys, Karen; Szabo, Gyongyi
Publisher(s):
Wiley-Blackwell
Tags:
Medicine; alcoholic liver disease; interleukin 1; interleukin 1 receptor antagonist; liver regeneration; Cell Biology; Cellular and Molecular Physiology; Digestive System Diseases; Gastroenterology; Hepatology
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article description
Inflammation and impaired hepatocyte regeneration contribute to liver failure in alcoholic hepatitis (AH). Interleukin (IL)-1 is a key inflammatory cytokine in the pathobiology of AH. The role of IL-1 in liver regeneration in the recovery phase of alcohol-induced liver injury is unknown.