Drosophilosophical: Re-thinking Adaptive Immunity in the Fly.

Citation data:

Cell, ISSN: 1097-4172, Vol: 169, Issue: 2, Page: 188-190

Publication Year:
2017
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Repository URL:
https://works.bepress.com/neal_silverman/73; https://escholarship.umassmed.edu/faculty_pubs/1290
PMID:
28388404
DOI:
10.1016/j.cell.2017.03.032
Author(s):
West, Cara C.; Silverman, Neal S.
Publisher(s):
Elsevier BV
Tags:
Biochemistry, Genetics and Molecular Biology; Immunity
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article description
For decades, flies have been a model for innate immunity. In this issue of Cell, Tassetto et al. describe a mechanism for antiviral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circles and the systemic dissemination of small-RNA-containing exosomes.