Drosophilosophical: Re-thinking Adaptive Immunity in the Fly.
- Citation data:
Cell, ISSN: 1097-4172, Vol: 169, Issue: 2, Page: 188-190
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- Repository URL:
- https://works.bepress.com/neal_silverman/73; https://escholarship.umassmed.edu/faculty_pubs/1290
- Biochemistry, Genetics and Molecular Biology; Immunity
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For decades, flies have been a model for innate immunity. In this issue of Cell, Tassetto et al. describe a mechanism for antiviral RNAi spreading that parallels mammalian adaptive immunity through reverse-transcribed vDNA circles and the systemic dissemination of small-RNA-containing exosomes.