Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk.

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Arteriosclerosis, thrombosis, and vascular biology, ISSN: 1524-4636, Vol: 33, Issue: 11, Page: 2666-73

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McManus, David D.; Beaulieu, Lea M.; Mick, Eric; Tanriverdi, Kahraman; Larson, Martin G.; Keaney, John F., Jr.; Benjamin, Emelia J.; Freedman, Jane E.
Ovid Technologies (Wolters Kluwer Health)
Medicine; UMCCTS funding; Aged; Blood Platelets; Body Weight; C-Reactive Protein; Cardiovascular Diseases; Female; Gene Expression; Humans; Immunologic Factors; Interleukin-6; Male; Massachusetts; Middle Aged; Obesity; RNA; Risk Factors; Cardiology; Cardiovascular Diseases; Epidemiology; Genetics and Genomics
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article description
Cardiovascular disease is a complex disorder influenced by interactions of genetic variants with environmental factors. However, there is no information from large community-based studies examining the relationship of circulating cell-specific RNA to inflammatory proteins. In light of the associations among inflammatory biomarkers, obesity, platelet function, and cardiovascular disease, we sought to examine the relationships of C-reactive protein (CRP) and interleukin-6 (IL-6) to the expression of key inflammatory transcripts in platelets.