NKp30 enables NK cells to act naturally with fungi.
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Cell host & microbe, ISSN: 1934-6069, Vol: 14, Issue: 4, Page: 369-71
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- Immunology and Microbiology; Candida; Cryptococcus; HIV Infections; *Host-Pathogen Interactions; Humans; *Immune Tolerance; Killer Cells, Natural; Natural Cytotoxicity Triggering Receptor 3; Immunology of Infectious Disease
NK cells have direct activity against fungal pathogens. Using an unbiased systematic approach, Li et al. (2013) find that NKp30 is a major NK cell receptor responsible for fungal recognition. Moreover, diminished NKp30 expression is associated with reduced antifungal activity in NK cells isolated from HIV-infected persons.