The pancreatic β-cell transcriptome and integrated-omics.

Citation data:

Current opinion in endocrinology, diabetes, and obesity, ISSN: 1752-2978, Vol: 21, Issue: 2, Page: 83-8

Publication Year:
2014
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Repository URL:
https://escholarship.umassmed.edu/gsbs_sp/1947
PMID:
24526012
DOI:
10.1097/med.0000000000000051
PMCID:
PMC4084684
Author(s):
Blodgett, David M; Cura, Anthony J; Harlan, David M
Publisher(s):
Ovid Technologies (Wolters Kluwer Health)
Tags:
Biochemistry, Genetics and Molecular Biology; Medicine; Nursing; Animals; Diabetes Mellitus; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genome-Wide Association Study; Glucose; Humans; Insulin; Insulin-Secreting Cells; Male; Mice; Organ Specificity; Sequence Analysis, RNA; Transcriptome; Endocrine System Diseases; Endocrinology, Diabetes, and Metabolism; Genetics and Genomics
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review description
β Cells represent one of many cell types in heterogeneous pancreatic islets and play the central role in maintaining glucose homeostasis, such that disrupting β-cell function leads to diabetes. This review summarizes the methods for isolating and characterizing β cells, and describes integrated 'omics' approaches used to define the β cell by its transcriptome and proteome.