Expression of collagenlike sequences by a tumor virus, herpesvirus saimiri

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Department of Pharmacology; Department of Molecular Genetics and Microbiology, Vol: 64, Issue: 7

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Geck, Peter; Whitaker, Scott A.; Medveczky, Maria M.; Medveczky, Peter G.
Base Sequence; Blotting, Northern; Blotting, Southern; Cloning, Molecular; Collagen; DNA, Viral; Gene Expression; *Genes, Viral; Herpesvirus 2, Saimiriine; Molecular Sequence Data; RNA, Messenger; Restriction Mapping; Sequence Homology, Nucleic Acid; Viral Structural Proteins; Life Sciences; Medicine and Health Sciences
article description
Sequencing demonstrates that the oncogenic regions of a group A strain and a group C strain of herpesvirus saimiri are nonhomologous. A bicistronic viral mRNA from this region is transcribed in tumor cells transformed by a highly oncogenic group C virus. The first open reading frame is homologous to collagen; no such sequences were found in group A or B strains. This is the first report that a virus encodes for sequences similar to those of a connective tissue protein.