Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells.

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PloS one, ISSN: 1932-6203, Vol: 7, Issue: 10, Page: e44915

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https://escholarship.umassmed.edu/oapubs/2372; https://works.bepress.com/gyongyi_szabo/154
10.1371/journal.pone.0044915; 10.1371/journal.pone.0044915.g001; 10.1371/journal.pone.0044915.g003; 10.1371/journal.pone.0044915.t001; 10.1371/journal.pone.0044915.t002; 10.1371/journal.pone.0044915.g004; 10.1371/journal.pone.0044915.g002
PMC3468613; 3468613
Angela Dolganiuc; Karen Kodys; Christopher Marshall; Banishree Saha; Shuye Zhang; Shashi Bala; Gyongyi Szabo; Fu-Sheng Wang
Public Library of Science (PLoS); Figshare
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; Chemistry; Immunology; iii; il-28; are; hcv; induce; myeloid; dendritic; cell-mediated; cells; treatment-induced; inhibitory; dcs; phenotype; il-10; Hepacivirus; Hepatitis C, Chronic; Interferon-alpha; Digestive System Diseases; Immunology and Infectious Disease; Virus Diseases; correlates; levels; proliferation; influences; analyses; generated; characteristics
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Hepatitis C virus (HCV) is difficult to eradicate and type III interferons (IFN-λ, composed of IL-28A, IL-28B and IL-29) are novel therapeutic candidates. We hypothesized that IFN-λ have immunomodulatory effects in HCV- infected individuals.