Reducing therapeutic misconception: A randomized intervention trial in hypothetical clinical trials.

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PloS one, ISSN: 1932-6203, Vol: 12, Issue: 9, Page: e0184224

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Paul P. Christopher; Paul S. Appelbaum; Debbie Truong; Karen Albert; Louise Maranda; Charles Lidz; Kerry Woolfall
Public Library of Science (PLoS)
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Bioethics and Medical Ethics; Clinical Trials; Health Services Administration; Health Services Research; Medical Education
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article description
Participants in clinical trials frequently fail to appreciate key differences between research and clinical care. This phenomenon, known as therapeutic misconception, undermines informed consent to clinical research, but to date there have been no effective interventions to reduce it and concerns have been expressed that to do so might impede recruitment. We determined whether a scientific reframing intervention reduces therapeutic misconception without significantly reducing willingness to participate in hypothetical clinical trials.