Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer.

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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, ISSN: 1055-9965, Vol: 14, Issue: 7, Page: 1697-702

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Kim, Jeri; Sun, Peiyu; Lam, Ying-Wai; Troncoso, Patricia; Sabichi, Anita L.; Babaian, Richard J.; Pisters, Louis L.; Pettaway, Curtis A.; Wood, Christopher G.; Lippman, Scott M.; McDonnell, Timothy J.; Lieberman, Ronald; Logothetis, Christopher; Ho, Shuk-Mei Show More Hide
American Association for Cancer Research (AACR)
Medicine; Analysis of Variance; Antioxidants; Double-Blind Method; Humans; Male; Middle Aged; Preoperative Care; Prostatectomy; Prostatic Neoplasms; Proteomics; Selenomethionine; Vitamin E; Oncology; Surgery; Urology
article description
Evidence of the chemopreventive effects of the dietary antioxidants alpha-tocopherol (vitamin E) and l-selenomethionine (selenium) comes from secondary analysis of two phase III clinical trials that found treatment with these antioxidants reduced the incidence of prostate cancer. To determine the effects of selenium and vitamin E in blood and prostate tissue, we undertook a preoperative feasibility study complementary to the currently ongoing Selenium and Vitamin E Cancer Prevention Trial.