Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer.

Citation data:

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, ISSN: 1055-9965, Vol: 14, Issue: 7, Page: 1697-702

Publication Year:
2005
Usage 272
Downloads 150
Abstract Views 122
Captures 18
Readers 17
Exports-Saves 1
Citations 21
Citation Indexes 21
Repository URL:
https://escholarship.umassmed.edu/oapubs/339
PMID:
16030104
DOI:
10.1158/1055-9965.epi-04-0679
Author(s):
Kim, Jeri; Sun, Peiyu; Lam, Ying-Wai; Troncoso, Patricia; Sabichi, Anita L.; Babaian, Richard J.; Pisters, Louis L.; Pettaway, Curtis A.; Wood, Christopher G.; Lippman, Scott M.; McDonnell, Timothy J.; Lieberman, Ronald; Logothetis, Christopher; Ho, Shuk-Mei Show More Hide
Publisher(s):
American Association for Cancer Research (AACR)
Tags:
Medicine; Analysis of Variance; Antioxidants; Double-Blind Method; Humans; Male; Middle Aged; Preoperative Care; Prostatectomy; Prostatic Neoplasms; Proteomics; Selenomethionine; Vitamin E; Oncology; Surgery; Urology
article description
Evidence of the chemopreventive effects of the dietary antioxidants alpha-tocopherol (vitamin E) and l-selenomethionine (selenium) comes from secondary analysis of two phase III clinical trials that found treatment with these antioxidants reduced the incidence of prostate cancer. To determine the effects of selenium and vitamin E in blood and prostate tissue, we undertook a preoperative feasibility study complementary to the currently ongoing Selenium and Vitamin E Cancer Prevention Trial.