The Interpeduncular nucleus is an unpaired, ovoid cell group at the base of the midbrain tegmentum. It is located in the mesencephalon below the interpeduncular fossa. As the name suggests, the interpeduncular nucleus lies in between the cerebral peduncles. CompositionThe Inte...
Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms.
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Current biology : CB, ISSN: 1879-0445, Vol: 23, Issue: 23, Page: 2327-35
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- Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Molecular and Cellular Neuroscience; Psychiatry; Psychiatry and Psychology; Substance Abuse and Addiction
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Chronic exposure to nicotine elicits physical dependence in smokers, yet the mechanism and neuroanatomical bases for withdrawal symptoms are unclear. As in humans, rodents undergo physical withdrawal symptoms after cessation from chronic nicotine characterized by increased scratching, head nods, and body shakes.