Activation of GABAergic neurons in the interpeduncular nucleus triggers physical nicotine withdrawal symptoms.

Citation data:

Current biology : CB, ISSN: 1879-0445, Vol: 23, Issue: 23, Page: 2327-35

Publication Year:
2013
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Repository URL:
https://escholarship.umassmed.edu/psych_pp/640
PMID:
24239118
DOI:
10.1016/j.cub.2013.09.041
PMCID:
PMC3855889
Author(s):
Zhao-Shea, Rubing; Liu, Liwang; Pang, Xueyan; Gardner, Paul D.; Tapper, Andrew R.
Publisher(s):
Elsevier BV; Cell Press
Tags:
Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences; Molecular and Cellular Neuroscience; Psychiatry; Psychiatry and Psychology; Substance Abuse and Addiction
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article description
Chronic exposure to nicotine elicits physical dependence in smokers, yet the mechanism and neuroanatomical bases for withdrawal symptoms are unclear. As in humans, rodents undergo physical withdrawal symptoms after cessation from chronic nicotine characterized by increased scratching, head nods, and body shakes.