Radiolabeled Zn-DPA as a potential infection imaging agent.

Citation data:

Nuclear medicine and biology, ISSN: 1872-9614, Vol: 39, Issue: 5, Page: 709-14

Publication Year:
2012
Usage 26
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Citations 19
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Repository URL:
https://escholarship.umassmed.edu/radiology_pubs/108
PMID:
22321532
DOI:
10.1016/j.nucmedbio.2011.12.006
Author(s):
Liu, Xinrong; Cheng, Dengfeng; Gray, Brian D.; Wang, Yuzhen; Akalin, Ali; Rusckowski, Mary; Pak, Koon Y.; Hnatowich, Donald J.
Publisher(s):
Elsevier BV
Tags:
Biochemistry, Genetics and Molecular Biology; Medicine; Zn-DPA; Streptavidin; Bacterial infection; Sterile inflammation; Imaging agent; Animals; Biotinylation; Chelating Agents; Fluorescent Dyes; Heterocyclic Compounds, 1-Ring; Inflammation; Isotope Labeling; Lipopolysaccharides; Mice; Multimodal Imaging; Nanoparticles; Organometallic Compounds; Picolinic Acids; Positron-Emission Tomography; Streptavidin; Streptococcal Infections; Streptococcus pyogenes; Tomography, X-Ray Computed; Bacterial Infections and Mycoses; Diagnosis; Medical Pathology; Pathology; Radiology
article description
A zinc-dipicolylamine analog (Zn-DPA) conjugated with a fluorophore (PSVue®794) has been shown to image bacterial infections in mice. However, radiolabeled Zn-DPA has not previously been considered for nuclear imaging of infection.