Radiolabeled Zn-DPA as a potential infection imaging agent.
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Nuclear medicine and biology, ISSN: 1872-9614, Vol: 39, Issue: 5, Page: 709-14
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- Biochemistry, Genetics and Molecular Biology; Medicine; Zn-DPA; Streptavidin; Bacterial infection; Sterile inflammation; Imaging agent; Animals; Biotinylation; Chelating Agents; Fluorescent Dyes; Heterocyclic Compounds, 1-Ring; Inflammation; Isotope Labeling; Lipopolysaccharides; Mice; Multimodal Imaging; Nanoparticles; Organometallic Compounds; Picolinic Acids; Positron-Emission Tomography; Streptavidin; Streptococcal Infections; Streptococcus pyogenes; Tomography, X-Ray Computed; Bacterial Infections and Mycoses; Diagnosis; Medical Pathology; Pathology; Radiology
A zinc-dipicolylamine analog (Zn-DPA) conjugated with a fluorophore (PSVue®794) has been shown to image bacterial infections in mice. However, radiolabeled Zn-DPA has not previously been considered for nuclear imaging of infection.