Comparing the intracellular fate of components within a noncovalent streptavidin nanoparticle with covalent conjugation.

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Nuclear medicine and biology, ISSN: 1872-9614, Vol: 39, Issue: 1, Page: 101-7

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Liu, Yuxia; Cheng, Dengfeng; Liu, Xinrong; Liu, Guozheng; Dou, Shuping; Xiao, Nan; Chen, Ling; Rusckowski, Mary; Hnatowich, Donald J.
Elsevier BV
Biochemistry, Genetics and Molecular Biology; Medicine; Nanoparticle; Antisense oligomer; Herceptin; Streptavidin; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biotin; Cell Line, Tumor; Drug Delivery Systems; Flow Cytometry; Humans; Indicators and Reagents; Indium Radioisotopes; Microscopy, Fluorescence; Nanoparticles; Neoplasms; Streptavidin; Vitamin B Complex; Cancer Biology; Medicinal-Pharmaceutical Chemistry; Nanomedicine; Oncology; Radiochemistry; Radiology
article description
Auger radiotherapy requires adequate tumor delivery and high nuclear accumulation and retention. We hypothesize that the noncovalent nature of a streptavidin/biotin three-component nanoparticle possessing these qualities may be required for dissociation of the radiolabeled oligomer and its accumulation into the cell nucleus.