Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1.
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Arthritis and rheumatism, ISSN: 0004-3591, Vol: 48, Issue: 5, Page: 1249-60
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- Immunology and Microbiology; Medicine; Arthritis, Rheumatoid; Blotting, Northern; Cell Line; Chondrocytes; DNA Primers; *DNA-Binding Proteins; Fibroblasts; Humans; Immunoenzyme Techniques; Interleukin-1; Lipopolysaccharides; Macrophages; NF-kappa B; Oligonucleotide Probes; Osteoarthritis; Osteoblasts; *Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; RNA, Messenger; Reverse Transcriptase Polymerase Chain Reaction; Synovial Membrane; Trans-Activators; *Transcription Factors; Tumor Necrosis Factor-alpha; Musculoskeletal Diseases; Rheumatology; Skin and Connective Tissue Diseases
To investigate the expression of the novel Ets transcription factor ESE-1 in rheumatoid synovium and in cells derived from joint tissues, and to analyze the role of nuclear factor kappaB (NF-kappaB) as one of the central downstream targets in mediating the induction of ESE-1 by proinflammatory cytokines.