Primary aldosteronism in patients with adrenal incidentaloma: Is screening appropriate for everyone?

Citation data:

Journal of clinical hypertension (Greenwich, Conn.), ISSN: 1751-7176, Vol: 20, Issue: 5, Page: 942-948

Publication Year:
2018
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Readers 5
Repository URL:
https://hsrc.himmelfarb.gwu.edu/smhs_medicine_facpubs/1213
PMID:
29722113
DOI:
10.1111/jch.13291
Author(s):
Stavropoulos, Konstantinos; Imprialos, Konstantinos P; Katsiki, Niki; Petidis, Konstantinos; Kamparoudis, Apostolos; Petras, Panagiotis; Georgopoulou, Vasiliki; Finitsis, Stefanos; Papadopoulos, Christodoulos; Athyros, Vasilios G; Doumas, Michael; Karagiannis, Asterios Show More Hide
Publisher(s):
Wiley
Tags:
Medicine; Medicine and Health Sciences
article description
Primary aldosteronism (PA) is a common form of secondary hypertension. Several guidelines recommend that patients with adrenal incidentaloma have a high probability of suffering from PA. We conducted a prospective study of 269 consecutive adults with adrenal incidentaloma to investigate the prevalence and clinical characteristics of PA. In total, 9 participants were detected with PA, suggesting a prevalence of 3.35% among the study population. PA participants had a higher blood pressure level by 14/20.8 mm Hg and a lower serum potassium level by 0.8 mmol/L (P < .05). Importantly, all patients with PA presented with concurrent indications (hypertension with or without hypokalemia) for screening of the disease, but they have not undergone relative screening by the referring physician, thus casting doubts about the appropriate implementation of current guidelines in real-life practice. Intense efforts are needed to familiarize physicians with recommendations for PA to minimize undiagnosed cases and the detrimental sequelae of this endocrine form of hypertension.