Schistosoma haematobium egg-induced bladder urothelial abnormalities dependent on p53 are modulated by host sex.
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Experimental parasitology, ISSN: 1090-2449, Vol: 158, Issue: 1, Page: 55-60
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- Immunology and Microbiology; Schistosoma haematobium--physiology; Schistosomiasis haematobia--pathology; Urinary Bladder--pathology; Schistosoma haematobium--physiology; Schistosomiasis haematobia--pathology; Urinary Bladder--pathology; Urology
The bladder urothelium changes dramatically during Schistosoma haematobium infection (urogenital schistosomiasis). These alterations include hyperplasia, ulceration, dysplasia, squamous metaplasia and frank carcinogenesis. Defining the pathways underpinning these urothelial responses will contribute to a deeper understanding of how S. haematobium egg expulsion, hematuria, and bladder cancer develop in humans. The tumor suppressor gene p53 is of particular interest, given its role in many cancers, including bladder cancer generally and schistosomal bladder cancer specifically.