Schistosoma haematobium egg-induced bladder urothelial abnormalities dependent on p53 are modulated by host sex.

Citation data:

Experimental parasitology, ISSN: 1090-2449, Vol: 158, Issue: 1, Page: 55-60

Publication Year:
2015
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Repository URL:
https://hsrc.himmelfarb.gwu.edu/smhs_uro_facpubs/37
PMID:
26160678
DOI:
10.1016/j.exppara.2015.07.002
PMCID:
PMC4656079
Author(s):
Hsieh, Michael H.; Honeycutt, Jared; Hammam, Olfat
Publisher(s):
Elsevier BV
Tags:
Immunology and Microbiology; Schistosoma haematobium--physiology; Schistosomiasis haematobia--pathology; Urinary Bladder--pathology; Schistosoma haematobium--physiology; Schistosomiasis haematobia--pathology; Urinary Bladder--pathology; Urology
article description
The bladder urothelium changes dramatically during Schistosoma haematobium infection (urogenital schistosomiasis). These alterations include hyperplasia, ulceration, dysplasia, squamous metaplasia and frank carcinogenesis. Defining the pathways underpinning these urothelial responses will contribute to a deeper understanding of how S. haematobium egg expulsion, hematuria, and bladder cancer develop in humans. The tumor suppressor gene p53 is of particular interest, given its role in many cancers, including bladder cancer generally and schistosomal bladder cancer specifically.