Crystallographic recognition controls peptide binding for bio-based nanomaterials.

Citation data:

Journal of the American Chemical Society, ISSN: 1520-5126, Vol: 133, Issue: 32, Page: 12346-9

Publication Year:
Usage 99
Abstract Views 99
Captures 77
Readers 74
Exports-Saves 3
Citations 70
Citation Indexes 70
Repository URL:
Coppage, Ryan; Slocik, Joseph M.; Briggs, Beverly D.; Frenkel, Anatoly I.; Heinz, Hendrik; Naik, Rajesh R.; Knecht, Marc R.
American Chemical Society (ACS)
Chemical Engineering; Chemistry; Biochemistry, Genetics and Molecular Biology; Engineering
article description
The ability to control the size, shape, composition, and activity of nanomaterials presents a formidable challenge. Peptide approaches represent new avenues to achieve such control at the synthetic level; however, the critical interactions at the bio/nano interface that direct such precision remain poorly understood. Here we present evidence to suggest that materials-directing peptides bind at specific time points during Pd nanoparticle (NP) growth, dictated by material crystallinity. As such surfaces are presented, rapid peptide binding occurs, resulting in the stabilization and size control of single-crystal NPs. Such specificity suggests that peptides could be engineered to direct the structure of nanomaterials at the atomic level, thus enhancing their activity.