Drug Eluting Electrospun Rubbery Fiber Mats

Citation data:

Abstracts of Papers of the American Chemical Society, Vol: 247, Issue: 301

Publication Year:
2014
Usage 23
Abstract Views 23
Repository URL:
http://ideaexchange.uakron.edu/polymerscience_ideas/819
Author(s):
Jindal, Aditya; Charif, Andrea A.; Friess, John; Puskas, Judit E.
Tags:
Engineering
conference paper description
This work reports release studies of acetylsalicylic acid (Aspirin), a model drug from electrospun ArbomatrixTM {a block copolymer with arborescent polyisobutylene (PIB) core and poly (para-methyl styrene) PMS end blocks} polymer fiber mats. ArbomatrixTM –PEG polymer solutions containing 15 and 30 wt% Aspirin were electrospun onto parchment paper to yield free-standing rubbery fiber mats. Aspirin release into phosphate buffered saline (PBS) solution (pH = 7.4) at 37oC was measured by UV spectroscopy. In three days 42 and 90% of the loaded Aspirin was released from the mats containing 15 and 30wt% Aspirin, respectively. Due to the excellent biocompatibility of ArbomatrixTM these mats hold great promise for drug delivery applications.