Butyl Rubber-Aliphatic Polyester Graft Copolymers for Biomedical Applications: Synthesis and Analysis of Chemical, Physical and Biological Properties

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https://ir.lib.uwo.ca/etd/1313; https://ir.lib.uwo.ca/cgi/viewcontent.cgi?article=2696&context=etd
Turowec, Bethany A
butyl rubber; biodegradable polymers; poly(caprolactone); poly(lactide); graft copolymer; thermoplastic elastomer; Biomaterials; Polymer Chemistry; Polymer Science
article description
Biomaterials can be used in a wide variety of medical applications owing to their breadth of characteristics that can be imparted by varying their chemical structures. Butyl rubber (IIR), which is a copolymer of isobutylene (IB) and small percentages of isoprene (IP), is particularly attractive as a biomaterial because of its elastomeric mechanical properties, biocompatibility, impermeability and high damping characteristics. IIR is typically vulcanized through chemical-based crosslinking mechanisms. However, these methods are not acceptable for biological applications. This thesis focuses on the synthesis of IIR-polyester graft copolymers by grafting biodegradable and biocompatible polyesters including poly(caprolactone) (PCL) and poly(d,l-lactide) (PDLLA) to the IIR backbone, and on the study of their properties.