Two dimensional angular domain optical imaging in biological tissues

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Ng, Eldon
Optical Imaging; angular domain imaging; angular filter array; trans-illumination imaging; Optics
article description
Optical imaging is a modality that can detect optical contrast within a biological sample that is not detectable with other conventional imaging techniques. Optical trans-illumination images of tissue samples are degraded by optical scatter. Angular Domain Imaging (ADI) is an optical imaging technique that filters scattered photons based on the trajectory of the photons. Previous angular filters were limited to one dimensional arrays, greatly limiting the imaging capability of the system.We have developed a 2D Angular Filter Array (AFA) that is capable of acquiring two dimensional projection images of a sample. The AFA was constructed using rapid prototyping techniques. The contrast and the resolution of the AFA was evaluated. The results suggest that a 2D AFA can be used to acquire two dimensional projection images of a sample with a reduced acquisition time compared to a scanning 1D AFA.