Unexpected widespread hypophosphatemia and bone disease associated with elemental formula use in infants and children.

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Bone, ISSN: 1873-2763, Vol: 97, Page: 287-292

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Gonzalez Ballesteros, Luisa F; Ma, Nina S; Gordon, Rebecca J; Ward, Leanne; Backeljauw, Philippe; Wasserman, Halley; Weber, David R; DiMeglio, Linda A; Gagne, Julie; Stein, Robert; Cody, Declan; Simmons, Kimber; Zimakas, Paul; Topor, Lisa Swartz; Agrawal, Sungeeta; Calabria, Andrew; Tebben, Peter; Faircloth, Ruth; Imel, Erik A; Casey, Linda; Carpenter, Thomas O Show More Hide
Elsevier BV; Elsevier Science
Medicine; Biochemistry, Genetics and Molecular Biology; Alkaline Phosphatase; Bone Diseases; Calcium; Child; Preschool; Female; Humans; Hypophosphatemia; Infant; Infant Formula; Male; Phosphorus; Rickets; Pediatrics
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Hypophosphatemia occurs with inadequate dietary intake, malabsorption, increased renal excretion, or shifts between intracellular and extracellular compartments. We noticed the common finding of amino-acid based elemental formula [EF] use in an unexpected number of cases of idiopathic hypophosphatemia occurring in infants and children evaluated for skeletal disease. We aimed to fully characterize the clinical profiles in these cases.