Maradolipids: diacyltrehalose glycolipids specific to dauer larva in Caenorhabditis elegans.

Citation data:

Angewandte Chemie (International ed. in English), ISSN: 1521-3773, Vol: 49, Issue: 49, Page: 9430-5

Publication Year:
2010
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Repository URL:
https://ir.uiowa.edu/nursing_pubs/911
PMID:
21053225
DOI:
10.1002/anie.201004466
Author(s):
Penkov, Sider; Mende, Fanny; Zagoriy, Vyacheslav; Erkut, Cihan; Martin, René; Pässler, Ulrike; Schuhmann, Kai; Schwudke, Dominik; Gruner, Margit; Mäntler, Jana; Reichert‐Müller, Thomas; Shevchenko, Andrej; Knölker, Hans‐Joachim; Kurzchalia, Teymuras V. Show More Hide
Publisher(s):
Wiley-Blackwell
Tags:
Chemical Engineering; Chemistry; Animals; Caenorhabditis elegans/chemistry/growth & development/metabolism; Glycolipids/chemistry/isolation & purification/metabolism; Larva/chemistry/growth & development/metabolism; Temperature; Nursing
article description
Don't stress: Maradolipids (see picture; red O, grey C, white H) are the first diacyltrehaloses found to be produced in animal organisms. The nematode Caenorhabditis elegans synthesizes maradolipids for the highly stress-resistant dauer larvae. Genetic knockout studies result in the improper morphology of the gut lumen of dauer larvae. Maradolipids might be important for understanding the chemical basis for the resistance of dauer larvae to extreme environmental stress. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.