Targeting vector to the urokinase plasminogen activator receptor

Publication Year:
2006

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Repository URL:
https://ir.uiowa.edu/patents/411; https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1410&context=patents
Author(s):
Welsh, Michael J.; Drapkin, Paola T.
Publisher(s):
United States Patent and Trademark Office
patent description
The present invention relates to the targeted delivery of a delivery vehicle construct which specifically binds to and stimulates endocytosis into cells expressing the urokinase plasminogen activator receptor (uPAR), and particularly human airway epithelia. The delivery vehicle construct comprises a portion of uPA and a cargo linked thereto and is useful for the targeted delivery of the cargo to a cell. In one aspect of the invention, the uPA portion of the delivery vehicle construct comprises the wild-type uPA, a fragment of uPA which has the PAI-1 binding region deleted, or a uPA peptide comprising amino acids 13–19 and is useful for the targeted delivery of the cargo to cells, and in particular to airway epithelia. The present invention also provides a method for delivering the delivery vehicle construct to a cell. The method comprises the steps of (a) contacting a target cell with a delivery vehicle construct comprising a uPA portion and a cargo portion; and (b) obtaining a desired result in the target cell.