Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.

Citation data:

Circulation research, ISSN: 1524-4571, Vol: 114, Issue: 5, Page: 792-805

Publication Year:
2014
Usage 171
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Citations 37
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Repository URL:
http://jdc.jefferson.edu/medfp/117
PMID:
24397980
DOI:
10.1161/circresaha.114.302439
PMCID:
PMC3961763
Author(s):
Wang, Yajing; Wang, Xiaoliang; Lau, Wayne Bond; Yuan, Yuexing; Booth, David; Li, Jing-Jing; Scalia, Rosario; Preston, Kyle; Gao, Erhe; Koch, Walter; Ma, Xin-Liang Show More Hide
Publisher(s):
Ovid Technologies (Wolters Kluwer Health); Lippincott Williams & Wilkins
Tags:
Biochemistry, Genetics and Molecular Biology; Medicine; Department of Pathology; Department of Medicine; Department of Emergency Medicine; Thomas Jefferson University; Adiponectin; Caveolin 1; Ceramidases; Endothelial Cells; Enzyme Activation; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Leukocyte Rolling; RNA; Small Interfering; Reactive Nitrogen Species; Reactive Oxygen Species; Receptors; Signal Transduction; Tumor Necrosis Factor-alpha; Vasculitis; Pathology
article description
Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered.