Adiponectin inhibits tumor necrosis factor-α-induced vascular inflammatory response via caveolin-mediated ceramidase recruitment and activation.
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Circulation research, ISSN: 1524-4571, Vol: 114, Issue: 5, Page: 792-805
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- Biochemistry, Genetics and Molecular Biology; Medicine; Department of Pathology; Department of Medicine; Department of Emergency Medicine; Thomas Jefferson University; Adiponectin; Caveolin 1; Ceramidases; Endothelial Cells; Enzyme Activation; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Leukocyte Rolling; RNA; Small Interfering; Reactive Nitrogen Species; Reactive Oxygen Species; Receptors; Signal Transduction; Tumor Necrosis Factor-alpha; Vasculitis; Pathology
Anti-inflammatory and vascular protective actions of adiponectin are well recognized. However, many fundamental questions remain unanswered.