Acetate causes alcohol hangover headache in rats.

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PloS one, ISSN: 1932-6203, Vol: 5, Issue: 12, Page: e15963

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10.1371/journal.pone.0015963; 10.1371/journal.pone.0015963.g004; 10.1371/journal.pone.0015963.g001; 10.1371/journal.pone.0015963.t001; 10.1371/journal.pone.0015963.g003; 10.1371/journal.pone.0015963.g005; 10.1371/journal.pone.0015963.g002; 10.3410/f.8249956.8661069
PMC3013144; 3013144
Christina R. Maxwell; Rebecca Jay Spangenberg; Jan B. Hoek; Stephen D. Silberstein; Michael L. Oshinsky; Efthimios M. C. Skoulakis
Public Library of Science (PLoS); Faculty of 1000, Ltd.; Figshare
Agricultural and Biological Sciences; Biochemistry, Genetics and Molecular Biology; Medicine; Thomas Jefferson University; Department of Neurology; Department of Pathology; Anatomy and Cell Biology; Acetaldehyde; Acetates; Alcohol Drinking; Alcoholic Intoxication; Analgesia; Animals; Chronic Disease; Ethanol; Headache; Hypersensitivity; Inflammation; Male; Nociceptors; Rats; Sprague-Dawley; Touch; Acetate; Alcohol Hangover Headache; neurology; thomas jefferson university; Neuroscience; Biotechnology; blocks; ethanol; induced; metabolism; dehydrogenase; acetaldehyde; aldehyde; analgesia; prevents; nociceptive; induces; biphasic; periorbital; tactile; causes; Neurology; Biological Phenomena, Cell Phenomena, and Immunity; Medical Cell Biology; Medical Neurobiology
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The mechanism of veisalgia cephalgia or hangover headache is unknown. Despite a lack of mechanistic studies, there are a number of theories positing congeners, dehydration, or the ethanol metabolite acetaldehyde as causes of hangover headache.