Molecular diagnostics in periprosthetic joint infection.
- Citation data:
The International journal of artificial organs, ISSN: 1724-6040, Vol: 34, Issue: 9, Page: 847-55
- Publication Year:
- Materials Science; Engineering; Chemical Engineering; Medicine; C-reactive protein; Joint arthroplasty; Leukocyte esterase; Periprosthetic join infection; Synovial fluid aspirate; C reactive protein; esterase; leukocyte enzyme; molecular marker; arthroplasty; debridement; enzyme linked immunosorbent assay; erythrocyte sedimentation rate; human; infectious arthritis; joint aspiration; joint prosthesis; leukocyte count; molecular diagnosis; periprosthetic joint infection; predictive value; prosthesis infection; receiver operating characteristic; review; sensitivity and specificity; synovial fluid; wound irrigation; 9007-41-4; 9013-79-0; Thomas Jefferson University Hospital; Rothman Institute; Philadelphia; Pennsylvania; United States; article; Orthopedics
Periprosthetic joint infection (PJI) is a significant and costly challenge to the orthopedic community. The lack of a gold standard for diagnosis remains the biggest obstacle in the detection and subsequent treatment of PJI. Molecular markers in the serum and joint fluid aspirate hold immense promise to enhance the development of a firm diagnostic criterion. The primary goal is one marker with high sensitivity and specificity. Here, we review our current research efforts in the field of molecular markers: C-reactive protein, erythrocyte sedimentation rate, white blood cells, and leukocyte esterase. Each marker has been studied to determine its sensitivity, specificity, and positive and negative predictive values in diagnosing PJI.