Pharmacokinetics of flunixin meglumine in mature swine after intravenous, intramuscular and oral administration.
- Citation data:
BMC veterinary research, ISSN: 1746-6148, Vol: 9, Issue: 1, Page: 165
- Publication Year:
- Repository URL:
- https://lib.dr.iastate.edu/ans_pubs/95; http://works.bepress.com/anna_butters-johnson/50; https://works.bepress.com/kenneth_stalder/153
- Veterinary; Swine; gilt; lameness; funixin meglumine; pharmacokinetics; NSAIDs; oral bioavailability
The purpose of this study was to determine intravenous (IV), intramuscular (IM) and oral (PO) FM PK in mature swine. Appropriate pain management for lameness in swine is a critical control point for veterinarians and producers, but science-based guidance on optimal housing, management and treatment of lameness is deficient. Six mature swine (121-168 kg) were administered an IV, IM, or PO dose of flunixin meglumine at a target dose of 2.2 mg/kg in a cross-over design with a 10 day washout period between treatments. Plasma samples collected up to 48 hours post-administration were analyzed by high pressure liquid chromatography and mass spectrometry (HPLC-MS) followed by non-compartmental pharmacokinetic analysis.