A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12.

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Page: 435-443

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Andrews, P W; Knowles, B B; Goodfellow, P N
Antibodies-Monoclonal: im; Antigens-Surface: ge; im; Cell-Line; Chromosomes-Human-6-12: ul; Fibrosarcoma: im; Human; Immunodiffusion; Immunosorbent-Techniques; Linkage-(Genetics); Mice; SUPPORT-NON-U-S-GOVT; SUPPORT-U-S-GOVT-P-H-S; Teratoma: im; Antigens-Surface: ge, im
article description
A murine monoclonal antibody 602-29, subclass IgG1, that recognizes an antigenic determinant expressed by most human cells is described. Immunoprecipitation and sodium dodecyl sulfate-gel electrophoresis analysis indicate that the antigenic determinant is carried by a protein with an apparent molecular weight of 21,000. The antigen is expressed by human-mouse somatic cell hybrids, and analysis of segregants that have lost human chromosomes indicates that the gene controlling expression of the 602-29 antigen is on chromosome 12.