Genes for epilepsy mapped in the mouse.
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- Chromosome-Mapping; Crosses-Genetic; Disease-Susceptibility: ge; Epilepsy: ge; Female; Male; Mice; Mice-Inbred-Strains; Mice-Neurologic-Mutants: ge; Recombination-Genetic; Seizures: ge; Software; SUPPORT-NON-U-S-GOVT; SUPPORT-U-S-GOVT-P-H-S
The neurological mutant mouse strain E1 is a model for complex partial seizures in humans. The inheritance of epileptic seizures with seven conventional chromosomal markers and over 60 endogenous proviral markers was studied by means of back-crosses of E1 with two seizure-resistant strains, DBA/2J and ABP/LeJ. The major gene responsible for this epileptic phenotype (El-1) was localized to a region distal with respect to the centromere on chromosome 9. At least one other gene, El-2, linked to proviral markers on chromosome 2, also influences the seizure phenotype. In addition, a potential modifier of seizures was detected in the DBA/2J background. The location of El-1 on distal chromosome 9 may allow identification of an epilepsy candidate gene in humans on the basis of conserved synteny with human chromosome 3.