Intestinal-specific PPARgamma deficiency enhances tumorigenesis in ApcMin/+ mice.

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International journal of cancer, ISSN: 0020-7136, Vol: 119, Issue: 10, Page: 2339-46

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McAlpine, Christen A; Barak, Yaacov; Matise, Ilze; Cormier, Robert T
Biochemistry, Genetics and Molecular Biology; Medicine; Colonic-Neoplasms; Disease-Progression; Female; Genes-APC; Genotype; Immunohistochemistry; Intestinal-Neoplasms; Male; Mice-Knockout; PPAR-gamma; Phenotype; Sex-Factors; Thiazoles; Thiazolidines
article description
Multiple investigations of the effects of peroxisome proliferator-activated receptor gamma (PPARgamma) ligands on colon cancer have produced contradictory results. While some studies demonstrated increased numbers of colonic polyps in Apc(Min/+) mice treated with various thiazolidinedione (TZD) PPARgamma ligands, others reported amelioration of tumor multiplicity and progression in both Apc(Min/+) mice and in mice with chemically-induced colon cancer. Here, we addressed the role of PPARgamma in murine intestinal tumorigenesis using gene knockout methodology. We found that either heterozygous or homozygous intestinal-specific PPARgamma deficiency enhanced the number of Apc(Min/+) tumors in both the small intestine and colon, especially in the colon, where PPARgamma deficiency also modulated tumor incidence. Gender significantly affected tumor multiplicity independent of PPARgamma genotype. Female Apc(Min/+) mice developed more tumors in the small intestine and more tumors overall, whereas male Apc(Min/+) mice developed more tumors in the colon. Nevertheless, intestinal PPARgamma deficiency enhanced tumorigenesis irrespective of gender. Our results suggest that PPARgamma functions as a tumor resistance factor in the mouse intestine and warrant further investigation of the PPARgamma-dependent and independent actions of TZDs in cancer.